Platelet-rich plasma is a concentrate of platelet-rich plasma protein derived from whole blood and works on the principle of density gradient centrifugation. Plasma is a component of blood that contains special 'Factors' or proteins that help blood to clot. It also contains proteins that support cell growth.

PRP contains different growth factors and other cytokines which may elicit gathering of stem cells around the damaged region stimulating cellular proliferation and tissue regeneration. PRP also contains growth factors that stimulate cellular growth and division. When the platelets in PRP are activated by thrombin, they release growth factors and other substances that serve to accelerate the wound-healing process by increasing cellular proliferation, matrix formation, osteoid production, connective tissue healing, angiogenesis, and collagen synthesis.